inflammatory drugs don t cut dementia risk
By Mary Brophy Marcus, USA TODAY
Millions of people who use non steroidal anti inflammatory drugs (NSAIDs), such as naproxen and ibuprofen, shouldn t bank on the drugs helping them ward off dementia.
A study in this week s Neupatagonia guide jacket 701rology suggests that NSAID users do not have lower rates of dementia and that increased use of the pain relievers may actually raise the risk of cognitive decline.
Researchers followed 2,736 members of Group Health who were an average age of 75 at the study s start. Partipatagonia addie boots women's 2011 closeoutcipants were tracked for 12 years to see if they developed dementia, including Alzheimer s dpatagonia capilene 1 reviewisease. Participants pharmacy records wepatagonia duffel reviewre evaluated for use of prescription and over the counter pain relievers, and they were questioned about their NSAID use as well.
ALZHEIMER S: What you need to knowResults showed 351 people had a history of heavy NSAID use at the study s start, while 107 people became heavy users during the follow up period. Heavy users took at least one NSAID a day for at least 16 months of a two year period.
Durinpatagonia fiona parka new adobeg the study, 476 people developed dementpatagonia pullovers for cheapia, and heavy NSAID users had a 66% higher risk of developing the condition than those with low or no use.
Larson says he was surprised at the outcome because inflammation is thought to play a role in dementia and because other studies suggested anti inflammatory pills lowered dementia risk.
We have years and years of drpatagonia outlet store floridaug exposure data that was extremely accurate. We did not expect these findings, patagonia guide jacket 703Larson says.
Duke aging expert Murali Doraiswamy says that the latest results aren t a revelation to him and that previous trials evaluating Vioxx, aspirin and prednisone, among other anti inflammatory medications, did not show reduced risks cognitive decline. Any benefits noted in prior studies were likely due to an epiphenomenon the people taking NSAIDS were younger, patagonia employee benefits guidehealthier and better educated, all of which biased the results.
The study doesn t disprove the theory that inflammation is a factor in Alzheimer s, though, says Jason Karlawish, associate direpatagonia guide jacket 700ctor of the Penn Memory Center at the University of Pennsylvania. Negative studies like this thapatagonia guide jacket 702t fail to prove the hypothesis leave thpatagonia flannel shirt bigousands of questions to be answered, Karlawish says.
The new data highlight the need for early detection and better biomarkers, says Alzheimer s Association vice president Bill Thies. If you could tell who s going to need depatagonia guide jacket 70mentia drugs at agpatagonia guide pants brandse 40 and study them, you may have a totally different result.
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